A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant omicron variant. Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
Levels of soluble complement regulators predict severity of COVID-19 symptomsArticle Published on 2022-10-182022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] analysed Analysis approach Asymptomatic baseline level Biomarkers cascade circulating Cohort complement Control Course COVID-19 COVID-19 patients Diagnosis disease disease severity driving dysregulation Elevation Evidence Factor Factor H factor H-related proteins FIVE Healthcare systems hospitalisation Hypothesis immune activation individual lack Level majority management mass spectrometry. Mild morbidity and mortality outcome outcomes Patient plasma sample predict Protein Proteins quantified responsible SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 virus severe COVID-19 severe disease severity of COVID-19 splice subset Support Symptom variant while with COVID-19 [DOI] 10.3389/fimmu.2022.1032331 PMC 바로가기
Sex differences in determinants of COVID-19 severe outcomes – findings from the National COVID Cohort Collaborative (N3C)Article Published on 2022-10-122022-11-15 Journal: BMC Infectious Diseases [Category] 바이오마커, [키워드] absolute lymphocyte absolute neutrophil adjusted adjusted odds ratio Admission age Analysis association averaged Biomarker Biomarkers both sexes CCI Charlson Comorbidity Index comorbid condition Comorbidities Comorbidity components COVID COVID-19 COVID-19 severity CRP death death rate defined determinant disease Elevation examined ferritin Health highlight hospital Hospitalized IMV Inflammation inflammatory biomarkers Invasive mechanical ventilation lab value Liver disease Logistic regression LOS lymphocytopenia magnitude male medication men men and women moderate to severe Mortality Myocardial infarction N-terminal neutrophil outcome Patient peptide Platelet Platelets predictor previous study Primary outcome procalcitonin Protein remained renal Research retrospective cohort risk risk factor risk of death secondary outcome Sex Sex difference sex differences. significantly solid tumor with COVID-19 women [DOI] 10.1186/s12879-022-07776-7 PMC 바로가기
Diagnostic Yield of Cardiac Biomarker Testing in Predicting Cardiac Disease and Multisystem Inflammatory Syndrome in Children in the Pandemic EraArticle Published on 2022-10-012022-11-15 Journal: Pediatric emergency care [Category] 바이오마커, [키워드] age Algorithm analyzed Biomarker cardiac cardiac disease children COVID-19 Critical demographics demonstrated diagnose diagnosed Diagnosis diagnostics elevated Elevation inclusion criteria Inflammatory initial MIS-C Multivariable regression analysis N-terminal Odds ratio outcome Patient patients pediatric peptide Primary outcome relationship Retrospective study Sensitivity and specificity single-center syndrome Testing women yield [DOI] 10.1097/PEC.0000000000002804 PMC 바로가기
C-reactive protein, immunothrombosis and venous thromboembolismArticle Published on 2022-09-132022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] activating amplifying appear binding Biomarker C-reactive protein classical Clinical data Clinical practice clinical utility Complement pathway condition conserved COVID-19 CRP destabilized dissociate Effect elevated Elevation Evidence Features immunothrombosis Infection Inflammation Inflammatory bowel disease Inflammatory response isoform marker membrane monomeric Pathogenesis Platelet pro-inflammatory pro-thrombotic Prophylactic Protein raise required Sepsis subset therapeutic strategy Thromboinflammation thrombosis tissue damage triggering utility Venous Thromboembolism venous thromboembolism. VTE VTE risk with COVID-19 [DOI] 10.3389/fimmu.2022.1002652 PMC 바로가기
Immune modulation as a consequence of SARS-CoV-2 infectionArticle Published on 2022-08-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] adaptive Alter alteration B cells CD3 CD8 Clinical severity clinically COVID-19 COVID-19 pathogenesis Cytokine storm D-dimer levels Decreased detrimental effects diagnosed elevated Elevation enrolled Frame healthy controls IFN-γ IgA level IgG IL-10 IL-6 IL-8 ILCs immune immune response Immunity Mild moderate modulated modulation negative correlation NK cell NK cells Patient Plasma cell pro-inflammatory cytokine Protective reduced reduction SARS-CoV-2 SARS-COV-2 infection Serum level severe COVID-19 disease Severe patient severe patients significantly subset T cell T cells T cells. the disease TNF-α [DOI] 10.3389/fimmu.2022.954391 PMC 바로가기
Age-Specific Changes in Virulence Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 변종 우려와 관련된 병독성의 연령별 변화Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Admission age all age groups association Canada change children Comorbidity concern coronavirus coronavirus 2 death Delta VOC delta VoCs Elevation Epidemiology estimate evaluate Factor greater group Health health outcomes Hospitalization ICU ICU admission increase in increases in individual individuals Infection intensive care intensive care unit logistic regression model Model novel Older outcome positive respiratory retrospective cohort risk risk of death SARS Coronavirus SARS coronavirus-2 SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severity Sex tested vaccination Vaccination Status variables variants of concern virulence virulence. VoC VOCs [DOI] 10.1093/cid/ciac174 PMC 바로가기 [Article Type] Article
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations Research Published on 2022-08-222022-10-05 Journal: Nature Communications [Category] 바이오마커, 치료법, [키워드] acute phase reactant adverse outcome approach caused cellular change Co-regulation conditions COVID-19 death defined Elevation growth hospitalized patients Human Infection Inflammation Inflammatory Ischemia laboratory measurement linear mechanism Myocardial infarction pathologic Platelet Population provide risk Sepsis tissue damage trajectory trauma WBC White blood cell [DOI] 10.1038/s41467-022-32222-2 [Article Type] Research
Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19Article Published on 2022-08-222022-11-15 Journal: JCI Insight [Category] SARS, 변종, 진단, 치료기술, [키워드] Analysis antibodies association asymptomatic infection C1q children CLL cohorts COVID-19 COVID-19 complications Degradation died disease Disease diagnosis disease severity dysregulation Elevation Genetic variant Infectious disease Inflammation Inflammatory lesion manifestation Manifestations MIS-C NET Neutrophil extracellular trap neutrophils. occur omicron organ Pathogenesis Patient patients pediatric Prevalence SARS-CoV-2 strains serum serum sample severity severity of COVID-19 significantly increased specific disease Support syndrome Variability variant [DOI] 10.1172/jci.insight.160332 PMC 바로가기
Pharmacogenetic variants and risk of remdesivir-associated liver enzyme elevations in Million Veteran Program participants hospitalized with COVID-19COVID-19로 입원한 백만 재향 군인 프로그램 참가자의 약물 유전적 변이 및 렘데시비르 관련 간 효소 상승 위험Article Published on 2022-08-012022-09-11 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted administration age Alanine alanine aminotransferase ALT assigned association baseline black Comorbidities components conducted coronavirus disease Coronavirus disease 2019 COVID-19 CYP2C19 drug Drug administration Elevation enzyme food Hospitalized Linear regression liver enzyme liver enzymes log-transformed Million Veteran Program multifactorial multivariable model participant Participants Patient pharmacogenetic phenotype receiving Remdesivir retrospective risk Sex stratified Treatment treatment initiation variant was performed white with COVID-19 [DOI] 10.1111/cts.13313 PMC 바로가기 [Article Type] Article